SOD-like Activity of Copper Salicylate Complex in Tween Micellar Systems

摘要

Copper salicylate complex has been synthesized and its composition was analyzed. The four surfactants(Tween-20, -40, -60, -80) were purified and their critical micelle concentrations(CMC) in phosphate buffer (pH=7.4) were measured. The SOD-like activity of copper salicylate complex was assayed using the cytochrome-c reduction method in different media. The cooperative effect of the complex with micelles was studied in detail. SOD-like activity of the complex was enhanced in the presence of surfactants. The four surfactants themselves display SOD-like activities to a certain extent. Similar results were obtained in the experiment for the antilipid peroxidation of red cell membrane. These results might be explained by the fact of micellar catalysis. It was suggested that the copper salicylate-Tween system used as a potential anti-inflammatory drug might be worthwhile to be further studied.