Enantioseparation of Zolmitriptan by HPLC

摘要

Aim To establish a HPLC method for the separation of the enantiomers of zolmitrip-tan. Methods The separations were performed on Chiralcel OJ column with hexane-ethanol-diethyl-amine(85:15:0.2) as mobile phase at a flow rate of 0. 8 mL·min~(-1) and detecttion wavelength of 227 nm at 35℃. Several related parameters for separation were studied. Results Baseline separation (Rs > 1.5) was easily obtained in the case, and the R-isomer impurity in zolmitriptan was determined. Conclusion The method developed in this study has been successfully applied for quality-control purposes.