Synthesis of Phenylalanine Analogs

摘要

A straightforward synthesis of phenylalanine analogs is described.Cerium ammonium nitrate (CAN) mediated addition of azide to cinnamic ester,followed by reaction with sodium acetate afforded the a-azidocin-namate in moderate yield.Hydrogenation of alpha-azidocinnamate,followed by BOC,CBZ or Fmoc protection gave phenylalanine analogs.A new approach for synthesizing racemic p-boronophenylalanine analog was also explored.