Easily Accessible 2-(2-Bromophenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane for Suzuki-Miyaura Reactions

摘要

A simple and direct method has been developed for the preparation of the title compound from 1,2-dibromobenzene. Suzuki-Miyaura reactions of this compound with substituted bromoaryls proceeded smoothly to give 2-bromobiphenyl derivatives in moderate to excellent yields. Instead of converting each of the bromoaryl compounds to the corresponding arylmetals followed by reacting with 2-iodobromoben-zene, the advantage of this protocol is that the substituted bromoaryls were used directly to couple with the title compound.