Synthesis, Characterization and Bioactivity Research of a Derivative of Secnidazole: 1-(2-Chloropropyl)-2-methyl-5-nitro-1H-imidazole

摘要

Abstract A secnidazole derivative, 1-(2-chloropropyl)-2-methyl-5-nitro-1H-imidazole (1), was synthesized and its single crystals were successfully grown in the mixture of ethanol/chloroform (3:1) by slow evaporation at room temperature. Its structure was confirmed by 1H NMR, 13C NMR, mass spectra, elemental analyses and X-ray single crystal diffraction. Crystal structure analysis revealed that 1 crystallized in the triclinic, space group P [`1] overline{1} with the following unit cell parameters: a = 6.5339(7) Ǻ, b = 7.5487(8) Ǻ, c = 9.7238(10) Ǻ, α = 92.894°(2), β = 96.165(2)°, γ = 102.710°(2), V = 463.78(8) Å3, Z = 2. Furthermore, this compound exhibited better anti-urease activity than secnidazole and acetyl-hydroxy acid when evaluated for antimicrobial activity against Helicobacter pylori.