Hepatic intraarterial chemotherapy with gemcitabine in patients with unresectable cholangiocarcinomas and liver metastases of pancreatic cancer: a clinical study on maximum tolerable dose and treatment efficacy

Thomas J. Vogl; Wolfram Schwarz; Katrin Eichler; Kathrin Hochmuth; Renate Hammerstingl; Ursula Jacob; Albert Scheller; Stephan Zangos; Matthias Heller

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Hepatic intraarterial chemotherapy with gemcitabine in patients with unresectable cholangiocarcinomas and liver metastases of pancreatic cancer: a clinical study on maximum tolerable dose and treatment efficacy

机译：吉西他滨肝动脉化疗方案治疗无法切除的胆管癌和胰腺癌肝转移的临床研究：最大耐受剂量和治疗效果的临床研究

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To define the maximum tolerated dose (MTD) of hepatic intraarterial chemotherapy with gemcitabine, administered with and without starch microspheres, in patients with inoperable intrahepatic cholangiocarcinomas and liver metastases of pancreatic carcinomas.

机译：定义在无法手术的肝内胆管癌和胰腺癌肝转移患者中，吉西他滨联合和不合并淀粉微球的肝动脉化疗的最大耐受剂量（MTD）。

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来源
《Journal of Cancer Research and Clinical Oncology》 |2006年第11期|745-755|共11页
作者
Thomas J. Vogl; Wolfram Schwarz; Katrin Eichler; Kathrin Hochmuth; Renate Hammerstingl; Ursula Jacob; Albert Scheller; Stephan Zangos; Matthias Heller;
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作者单位

Institute for Diagnostic and Interventional Radiology Johann Wolfgang Goethe-University Clinic Theodor-Stern-Kai 7 60590 Frankfurt am Main Germany;

Institute for Diagnostic and Interventional Radiology Johann Wolfgang Goethe-University Clinic Theodor-Stern-Kai 7 60590 Frankfurt am Main Germany;

Institute for Diagnostic and Interventional Radiology Johann Wolfgang Goethe-University Clinic Theodor-Stern-Kai 7 60590 Frankfurt am Main Germany;

Institute for Diagnostic and Interventional Radiology Johann Wolfgang Goethe-University Clinic Theodor-Stern-Kai 7 60590 Frankfurt am Main Germany;

Institute for Diagnostic and Interventional Radiology Johann Wolfgang Goethe-University Clinic Theodor-Stern-Kai 7 60590 Frankfurt am Main Germany;

Department of Oncology Heilbrunn Oncological Clinic Heilbrunn Leonardis Clinic Abt-Walther-Weg 15-16 83670 Bad Heilbrunn Germany;

Department of Oncology Heilbrunn Oncological Clinic Heilbrunn Leonardis Clinic Abt-Walther-Weg 15-16 83670 Bad Heilbrunn Germany;

Institute for Diagnostic and Interventional Radiology Johann Wolfgang Goethe-University Clinic Theodor-Stern-Kai 7 60590 Frankfurt am Main Germany;

Institute for Diagnostic and Interventional Radiology Johann Wolfgang Goethe-University Clinic Theodor-Stern-Kai 7 60590 Frankfurt am Main Germany;

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正文语种 eng
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关键词
Liver metastases; Intraarterial chemotherapy; Gemcitabine; Cholangiocarcinomas;

机译：肝转移;动脉内化疗;吉西他滨;胆管癌;

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专利

1. Hepatic intraarterial chemotherapy with gemcitabine in patients with unresectable cholangiocarcinomas and liver metastases of pancreatic cancer: a clinical study on maximum tolerable dose and treatment efficacy. [J] . Vogl TJ, Schwarz W, Eichler K, Journal of Cancer Research and Clinical Oncology . 2006,第11期

机译：吉西他滨对不可切除的胆管癌和胰腺癌肝转移患者的肝动脉化疗：最大耐受剂量和治疗效果的临床研究。
2. Treatment intensification with hepatic arterial infusion chemotherapy in patients with liver-only colorectal metastases still unresectable after systemic induction chemotherapy – a randomized phase II study -- SULTAN UCGI 30/PRODIGE 53 (NCT03164655)- study protocol [J] . Alice Boilève, Aline Maillard, Mathilde Wagner, BMC Cancer . 2020,第1期

机译：肝动脉输液化疗的治疗肝脏肝脏输液化疗患者肝脏直肠转移患者仍然不可切除，后系统诱导化疗后仍然不可切除 - 一种随机期II研究 - 苏丹UCGI 30 / PRODIGE 53（NCT03164655） - 研究方案 - 研究方案
3. Hepatic Arterial Infusion Chemotherapy of 5-Fluorouracil for Patients with Unresectable Liver Metastases from Colorectal Cancer Refractory to Standard Systemic Chemotherapy: A Multicenter Retrospective Study [J] . Sato Yozo, Inaba Yoshitaka, Aramaki Takeshi, Oncology: International Journal of Cancer Research and Treatment . 2020,第5期

机译：肝脏动脉输液化疗5氟尿嘧啶，对结直肠癌难以切除的肝脏转移患者标准全身化疗：多中心回顾性研究
4. Ultrasound microbubble targeted gemcitabine delivery for pancreatic cancer treatment [C] . Lauren J. Jablonowski, John R. Eisenbrey, David Brown, IEEE International Ultrasonics Symposium . 2017

机译：超声微泡靶向吉西他滨递送治疗胰腺癌
5. Predictive factors of the treatment outcome in patients with advanced biliary tract cancer receiving gemcitabine plus cisplatin as first-line chemotherapy [D] . 鈴木, 裕子 2019

机译：吉西他滨联合顺铂一线化疗对晚期胆道癌患者治疗效果的预测因素
6. Pilot study of hepatic arterial infusion chemotherapy with gemcitabine and 5-fluorouracil for patients with postoperative liver metastases from pancreatic cancer [O] . HIDEHIRO TAJIMA, TETSUO OHTA, HIROHISA KITAGAWA, -1

机译：吉西他滨和5-氟尿嘧啶肝动脉灌注化疗对胰腺癌术后肝转移患者的初步研究
7. Hepatic arterial infusion chemotherapy with gemcitabine and 5-fluorouracil or oral S-1 improves the prognosis of patients with postoperative liver metastases from pancreatic cancer [O] . HIDEHIRO TAJIMA, HIROHISA KITAGAWA, TOMOYA TSUKADA, 2013

机译：具有吉西他滨和5-氟尿嘧啶或口服S-1的肝动脉输注化疗改善了胰腺癌术后肝转移患者的预后

Hepatic intraarterial chemotherapy with gemcitabine in patients with unresectable cholangiocarcinomas and liver metastases of pancreatic cancer: a clinical study on maximum tolerable dose and treatment efficacy

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