Downregulation of EphA2 expression suppresses the growth and metastasis in squamous-cell carcinoma of the head and neck in vitro and in vivo

Yong Liu; Changyun Yu; Yuanzheng Qiu; Donghai Huang; Xiaojuan Zhou; Xin Zhang; Yongquan Tian

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Downregulation of EphA2 expression suppresses the growth and metastasis in squamous-cell carcinoma of the head and neck in vitro and in vivo

机译：EphA2表达的下调在体外和体内抑制了头颈部鳞状细胞癌的生长和转移

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摘要

Our previous study has revealed that EphA2 overexpression is significantly associated with aggressive behavior and poor prognosis in patients with squamous-cell carcinoma of the head and neck (SCCHN). However, the function of EphA2 in tumorigenesis and cervical lymph node metastasis of SCCHN has never been elucidated in vivo.

机译：我们以前的研究表明，EphA2过表达与头颈部鳞状细胞癌（SCCHN）患者的侵略行为和不良预后密切相关。然而，体内尚未阐明EphA2在SCCHN的肿瘤发生和宫颈淋巴结转移中的功能。

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来源
《Journal of Cancer Research and Clinical Oncology 》 |2012年第2期| p.195-202| 共8页
作者
Yong Liu; Changyun Yu; Yuanzheng Qiu; Donghai Huang; Xiaojuan Zhou; Xin Zhang; Yongquan Tian;
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作者单位

Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Xiangya Road 87, Changsha, 410008, Hunan Province, People’s Republic of China;

Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Xiangya Road 87, Changsha, 410008, Hunan Province, People’s Republic of China;

Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Xiangya Road 87, Changsha, 410008, Hunan Province, People’s Republic of China;

Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Xiangya Road 87, Changsha, 410008, Hunan Province, People’s Republic of China;

Department of Otolaryngology, No.1 Hospital of Changsha City, Changsha, 410013, Hunan, China;

Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Xiangya Roa;

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正文语种 eng
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关键词
Head and neck cancer; Squamous-cell carcinoma; Metastasis; Prognosis; EphA2;

机译：头颈癌;鳞状细胞癌;转移;预后;EphA2;

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专利

1. Downregulation of EphA2 expression suppresses the growth and metastasis in squamous-cell carcinoma of the head and neck in vitro and in vivo [J] . LiuY., YuC., QiuY., Journal of Cancer Research and Clinical Oncology . 2012 ,第2期

机译：EphA2表达下调在体外和体内抑制头颈部鳞状细胞癌的生长和转移
2. Clinical significance of EphA2 expression in squamous-cell carcinoma of the head and neck. [J] . Liu Y, Zhang X, Qiu Y, Journal of Cancer Research and Clinical Oncology . 2011 ,第5期

机译：EphA2在头颈部鳞状细胞癌中表达的临床意义。
3. Clinical significance of EphA2 expression in squamous-cell carcinoma of the head and neck [J] . Yong Liu, Xin Zhang, Yuanzheng Qiu, Journal of Cancer Research and Clinical Oncology . 2011 ,第5期

机译：EphA2表达在头颈部鳞状细胞癌中的临床意义
4. Adenylyl Cyclase-Associated Protein 1 in Metastasis of Squamous Cell Carcinoma of the Head and Neck and Non-Small Cell Lung Cancer [C] . G. V. Kakurina, E. S. Kolegova, O. V. Cheremisina, International Conference on Physics of Cancer . 2016

机译：腺苷酸环酶相关蛋白1在头部和颈部和非小细胞肺癌的鳞状细胞癌转移中
5. Epidermal growth factor receptor (EGFR) gene expression and its related biomarkers in head and neck squamous cell carcinoma (HNSCC) [D] . Hauser, Belinda R. 2008

机译：表皮生长因子受体（EGFR）基因表达及其相关的生物标志物在头颈部鳞状细胞癌（HNSCC）中
6. Lentiviral RNA interference-mediated downregulation of Forkhead box M1 expression suppresses growth of oral squamous cell carcinoma in vitro [O] . Jing Qiu, Juan Zhao, Anjun Zuo, -1

机译：慢病毒RNA干扰介导的叉头盒M1表达下调抑制口腔鳞状细胞癌的体外生长
7. Restoration of caveolin-1 expression suppresses growth and metastasis of head and neck squamous cell carcinoma [O] . Zhang, H, Su, L, Müller, S, 2008

机译：Caveolin-1表达的恢复抑制头颈部鳞状细胞癌的生长和转移

Downregulation of EphA2 expression suppresses the growth and metastasis in squamous-cell carcinoma of the head and neck in vitro and in vivo

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