Modularized study of human calcium signalling pathway

摘要

Signalling pathways are complex biochemical networks responsible for regulation of numerous cellular functions. These networks function by serial and successive interactions among a large number of vital biomolecules and chemical compounds. For deciphering and analysing the underlying mechanism of such networks, a modularized study is quite helpful. Here we propose an algorithm for modularization of calcium signalling pathway of H. sapiens. The idea that “a node whose function is dependant on maximum number of other nodes tends to be the center of a subnetwork” is used to divide a large signalling network into smaller subnetworks. Inclusion of node(s) into subnetworks(s) is dependant on the outdegree of the node(s). Here outdegree of a node refers to the number of relations of the considered node lying outside the constructed subnetwork. Node(s) having more than c relations lying outside the expanding subnetwork have to be excluded from it. Here c is a specified variable based on user preference, which is finally fixed during adjustments of created subnetworks, so that certain biological significance can be conferred on them.