Stereodependent Fusion and Fission of Vesicles: Calcium Binding of Synthetic Gemini Phospholipids Containing Two Phosphate Groups

摘要

Three different stereoisomers of a phosphatidic acid analog bearing two phosphate groups have been synthesized from tartaric acid and erythritol. The obtained diastereomeric Gemini surfactants differ in their aggregation behavior due to the different spatial orientations of their functional groups. The most remarkable difference in aggregation behavior is encountered when calcium ions are added to vesicle suspensions of the respective isomers.