Asymmetric [3 + 2] Cycloaddition of 2,3-Butadienoates with Electron-Deficient Olefins Catalyzed by Novel Chiral 2,5-Dialkyl-7-phenyl-7- phosphabicyclo[2.2.1]heptanes

摘要

In conclusion, we have developed a new family of chiral phosphines with a unique fused bicyclic [2.2.1]ring structure. A[3+2]cycloaddition between 2, 3-butadienoates and electron- deficient olefins catalyzed by these chiral monophosphines gives cyclopentene products with excellent regioselectivity and enan- tioselectivity. This method is a potentially powerful tool for the synthesis of chiral cyclopentanoids.