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An evaluation of the toxicological aspects and potential doses from the inhalation of coal combustion products

机译:吸入煤燃烧产物的毒理学方面和潜在剂量的评估

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This paper reviews toxicological literature pertaining to coal combustion products (CCPs) inhalation and presents case studies on the inhalation of CCPs from the Kingston Fossil Plant area and from the Colbert Fossil Plant CCP landfill site. While most research regarding coal plant emissions focuses on fly ash, this article takes a holistic approach to examining not only emitted particulate matter such as fly ash, but also the theoretical calculated doses of landfilled CCPs. Furthermore, these doses are compared to in vitro and in vivo studies in order to highlight differences between laboratory-based studies and to emphasize the difficulty in extrapolating effects from inhalation exposures. In both case studies, fugitive emissions from the Kingston ash spill or the Colbert CCP-handling operations did not exceed any national ambient air quality standards or reference concentrations for individual components. Adverse effects such as mild pulmonary inflammation noted in the reviewed literature were in response to doses much higher than would be likely to occur in humans exposed to landfilled CCPs. We conclude that the doses for fugitive emissions calculated herein do not appear to be high enough to elicit a measurable adverse response in humans.
机译:本文回顾了与煤燃烧产物(CCPs)吸入有关的毒理学文献,并介绍了从金斯敦化石工厂地区和科尔伯特化石工厂CCP垃圾填埋场吸入CCP的案例研究。尽管大多数关于燃煤电厂排放的研究都集中在粉煤灰,但本文采用整体方法不仅检查了粉煤灰等排放的颗粒物,还检查了填埋的CCP的理论计算剂量。此外,将这些剂量与体外和体内研究进行了比较,以强调基于实验室的研究之间的差异,并强调难以从吸入暴露中推断出效应。在两个案例研究中,金士顿粉尘泄漏或科尔伯特CCP处理操作产生的逸散排放均未超过任何国家环境空气质量标准或单个组件的参考浓度。综述文献中指出的不良反应(如轻度肺部炎症)是对剂量的响应,该剂量要比暴露于填埋的CCP的人可能发生的剂量高得多。我们得出的结论是,本文计算出的逃逸剂量似乎不足以引起人类可测量的不良反应。

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    Eric N. Liberda; Lung Chi Chen;

  • 作者单位

    School of Occupational and Public Health, Ryerson University, Toronto, Ontario, Canada,Department of Environmental Medicine, New York University, Tuxedo, New York, USA;

    Department of Environmental Medicine, New York University, Tuxedo, New York, USA;

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