Novel glucocorticoid antedrugs possessing a 21-(γ-lactone) ring

摘要

A series of novel pregnane derivatives bearing γ-butyrolactones at C21 were prepared and tested as glucocorticoidnagonists. The compounds were also tested for their lability in human plasma, and found to be rapidly hydrolysed bynthe enzyme paraoxonase to the respective hydroxyacids.