Phase I/II Trial of Hyperfractionated Accelerated Chemoradiotherapy for Unresectable Advanced Pancreatic Cancer

Masanori Tsujie; Shoji Nakamori; Eiichi Tanaka; Hiroaki Nagano; Koji Umeshita; Keizo Dono; Masato Sakon; Takehiro Inoue; Toshihiko Inoue; and Morito Monden

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Phase I/II Trial of Hyperfractionated Accelerated Chemoradiotherapy for Unresectable Advanced Pancreatic Cancer

机译：I / II期超分割加速化放疗治疗无法切除的晚期胰腺癌

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Background: We conducted a Phase I/II study to evaluate the local efficacy and toxicity of hyperfractionated accelerated radiotherapy (HART) combined with 5-fluorouracil (5-FU) and cisplatin (CDDP) in patients with unresectable advanced pancreatic cancer.

机译：背景：我们进行了I / II期研究，以评估超分割加速放疗（HART）与5-氟尿嘧啶（5-FU）和顺铂（CDDP）联合治疗不可切除的晚期胰腺癌的局部疗效和毒性。

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来源
《Japanese Journal of Clinical Oncology》 |2006年第8期|504-510|共7页
作者
Masanori Tsujie; Shoji Nakamori; Eiichi Tanaka; Hiroaki Nagano; Koji Umeshita; Keizo Dono; Masato Sakon; Takehiro Inoue; Toshihiko Inoue; and Morito Monden;
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作者单位

Department of Surgery and Clinical Oncology Graduate School of Medicine Osaka University Suita Osaka;

Department of Radiology Graduate School of Medicine Osaka University Suita Osaka;

Department of Multidisciplinary Radiotherapy Graduate School of Medicine Osaka University Suita Osaka;

Department of Surgery Cancer Center Department of Molecular Medicine Osaka National Hospital National Hospital Organization Osaka and;

Department of Radiotherapy Osaka Medical Center for Cancer and Cardiovascular Diseases Osaka Japan;

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1. Phase I/II trial of hyperfractionated accelerated chemoradiotherapy for unresectable advanced pancreatic cancer. [J] . Tsujie M, Nakamori S, Tanaka E, Japanese journal of clinical oncology. . 2006,第8期

机译：超分割加速放化疗的I / II期临床试验不可切除的晚期胰腺癌。
2. Locally advanced unresectable pancreatic cancer: Induction chemoradiotherapy followed by maintenance gemcitabine versus gemcitabine alone: Definitive results of the 2000-2001 FFCD/SFRO phase III trial [J] . Barhoumi M, Mornex F, Bonnetain F, Cancer radiotherapie: journal de la Soci閠?fran鏰ise de radiotherapie oncologique . 2011,第3期

机译：局部晚期不可切除的胰腺癌：诱导放化疗，继之维持吉西他滨与单用吉西他滨：2000-2001 FFCD / SFRO III期试验的明确结果
3. Phase III trial comparing intensive induction chemoradiotherapy (60 Gy, infusional 5-FU and intermittent cisplatin) followed by maintenance gemcitabine with gemcitabine alone for locally advanced unresectable pancreatic cancer. Definitive results of the 2000–01 FFCD/SFRO study [J] . Chauffert B, Mornex F, Bonnetain F, Annals of oncology: official journal of the European Society for Medical Oncology . 2008,第9期

机译：III期试验比较了密集诱导放化疗（60 Gy，5-FU输注和间断顺铂），然后单独使用吉西他滨维持吉西他滨治疗局部晚期不可切除的胰腺癌。 2000-01年FFCD / SFRO研究的最终结果
4. Phase I/II clinical trials on the effect of weekly paclitaxel (wPTX) and wPTX containing combination regimens for advanced and metastatic gastric cancer -ECRIN group studies [C] . Sakamoto J, Kodera Y, Kobayashi M, International Gastric Cancer Congress . 2009

机译：I / II期临床试验关于每周紫杉醇（WPTX）和WPTX含有晚期和转移性胃癌组合方案的临床试验 - 分泌组研究
5. Clinical predictive value of pre-clinical cancer models: A study of the predictive value of the in vitro cell line, human xenograft and murine allograft pre-clinical cancer models for phase II clinical trials of cytotoxic cancer drugs [D] . Voskoglou-Nomikos, Theodora 2001

机译：临床前癌症模型的临床预测价值：体外细胞系，人异种移植和小鼠同种异体移植临床前癌症模型对细胞毒性癌症药物II期临床试验的预测价值研究
6. Phase II study of chemoradiotherapy combined with gemcitabine plus nab-paclitaxel for unresectable locally advanced pancreatic ductal adenocarcinoma (NUPAT 05 Trial): study protocol for a single arm phase II study [O] . Nao Takano, Suguru Yamada, Akihiro Hirakawa, 2019

机译：放化疗联合吉西他滨联合纳布紫杉醇用于不可切除的局部晚期胰腺导管腺癌的II期研究（NUPAT 05试验）：单臂II期研究的研究方案
7. Preoperative hyperfractionated accelerated radiotherapy (HART) in locally advanced rectal cancer (LARC) immediately followed by surgery. A prospective phase II trial [O] . Philippe A. Coucke, Markus Notter, Bernhard Stamm, 2006

机译：在局部晚期直肠癌（LARC）的术前高压加速放疗（HART）立即进行手术。潜在第二阶段试验

Phase I/II Trial of Hyperfractionated Accelerated Chemoradiotherapy for Unresectable Advanced Pancreatic Cancer

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