Safety, Efficacy, and Immunogenicity of 2 Doses of Bovine-Human (UK) and Rhesus–Rhesus-Human Rotavirus Reassortant Tetravalent Vaccines in Finnish Children

Timo Vesikari; Aino V. Karvonen; Jukka Majuri; Shang-Qin Zeng; Xiao-Li Pang; Robert Kohberger; Bruce D. Forrest; Yasutaka Hoshino; Robert M. Chanock; and Albert Z. Kapikian

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Safety, Efficacy, and Immunogenicity of 2 Doses of Bovine-Human (UK) and Rhesus–Rhesus-Human Rotavirus Reassortant Tetravalent Vaccines in Finnish Children

机译：芬兰儿童中的2剂牛-人（英国）和恒河猴-人-轮状病毒重配四价疫苗的安全性，有效性和免疫原性

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BackgroundLive oral rhesus–rhesus-human rotavirus reassortant tetravalent (RRV-TV) vaccine was efficacious against rotavirus gastroenteritis but was withdrawn because of a rare association with intussusception. A corresponding tetravalent (types G1, G2, G3, and G4) reassortant vaccine based on bovine-human (UK) rotavirus reassortant tetravalent (BRV-TV) vaccine was developed concurrently

机译：背景口服恒河猴-恒河猴-人类轮状病毒重配四价（RRV-TV）疫苗可有效抵抗轮状病毒肠胃炎，但因与肠套叠的罕见关联而被撤回。同时开发了基于牛-人（英国）轮状病毒重配四价（BRV-TV）疫苗的相应四价（G1，G2，G3和G4型）重配疫苗

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《Journal of Infectious Diseases》 |2006年第3期|370-376|共7页
作者
Timo Vesikari; Aino V. Karvonen; Jukka Majuri; Shang-Qin Zeng; Xiao-Li Pang; Robert Kohberger; Bruce D. Forrest; Yasutaka Hoshino; Robert M. Chanock; and Albert Z. Kapikian;
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作者单位

Vaccine Research Center University of Tampere Medical School Tampere Finland;

Wyeth Vaccine Research Pearl River New York;

Laboratory of Infectious Diseases National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda Maryland;

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1. Safety, Efficacy, and Immunogenicity of 2 Doses of Bovine-Human (UK) and Rhesus-Rhesus-Human Rotavirus Reassortant Tetravalent Vaccines in Finnish Children. [J] . Vesikari T, Karvonen AV, Majuri J, The Journal of Infectious Diseases . 2006,第3期

机译：芬兰儿童中的2剂量牛-人（英国）和恒河猴-人-轮状病毒重配四价疫苗的安全性，有效性和免疫原性。
2. Safety and efficacy of high-dose rhesus-human reassortant rotavirus vaccines--report of the National Multicenter Trial. United States Rotavirus Vaccine Efficacy Group. [J] . Rennels MB, Glass RI, Dennehy PH, Pediatrics: Official Publication of the American Academy of Pediatrics . 1996,第1期

机译：大剂量恒河猴-人类重配轮状病毒疫苗的安全性和有效性-国家多中心试验报告。美国轮状病毒疫苗功效小组。
3. Rotaviruses detected by reverse transcription polymerase chain reaction in acute gastroenteritis during a trial of rhesus-human reassortant rotavirus tetravalent vaccine: implications for vaccine efficacy analysis. [J] . Pang XL, Joensuu J, Hoshino Y, Journal of clinical virology: The official publication of the Pan American Society for Clinical Virology . 1999,第1a2期

机译：逆转录聚合酶链反应检测在急性胃肠炎中检测的Rhehus-Lean Realsortant rotavirus Tetravalent疫苗中的旋转刺激：对疫苗疗效分析的影响。
4. Efficacy and safety of a two dose one bottle porcine circoims/Mycoplasma hyopneumoniae combination vaccine [C] . J. W. Bubolz, D. S. Fredrickson, V.J. Rapp-Gabrielson, Annual^Meeting of the American Association^of^Swine^Veterinarians. . 2014

机译：两剂量的疗效和安全性，一瓶瓶猪圈 IMS / mycoplasma yecopneumoniae组合疫苗
5. A rhesus monkey model of respiratory syncytial virus (RSV) to evaluate the immunogenicity and protective efficacy of a DNA vaccine. [D] . Vaughan, Kerrie Colleen McArthur. 2002

机译：呼吸道合胞病毒（RSV）的恒河猴模型，用于评估DNA疫苗的免疫原性和保护功效。
6. Immunogenicity safety and efficacy of tetravalent rhesus-human reassortant rotavirus vaccine in Belém Brazil. [O] . A. C. Linhares, Y. B. Gabbay, J. D. Mascarenhas, 1996

机译：巴西贝伦的四价恒河猴-人类重配轮状病毒疫苗的免疫原性安全性和有效性。
7. Nutritional status in relation to the efficacy of the rhesus-human reassortant, tetravalent rotavirus vaccine (RRV-TV) in infants from Belém, Pará State, Brazil Relação entre o estado nutricional e a eficácia da vacina tetravalente contra rotavírus de origem símio-humana, geneticamente rearranjada (RRV-TV), em crianças de Belém, Pará, Brasil [O] . Alexandre C. LINHARES, Kênea B. do CARMO, Krynssya K. OLIVEIRA, 2002

机译：巴西帕拉州贝伦婴儿恒河猴 - 人重配株，四价轮状病毒疫苗（RRV-TV）的营养状况来自巴西帕拉贝伦的儿童重新安排（RRV-TV）

Safety, Efficacy, and Immunogenicity of 2 Doses of Bovine-Human (UK) and Rhesus–Rhesus-Human Rotavirus Reassortant Tetravalent Vaccines in Finnish Children

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