A New Recombinant Bacille Calmette-Guérin Vaccine Safely Induces Significantly Enhanced Tuberculosis-Specific Immunity in Human Volunteers

Daniel F. Hoft1 Azra Blazevic1 Getahun Abate1 Willem A. Hanekom5 Gilla Kaplan2 Jorge H. Soler2 Frank Weichold3 Larry Geiter3 Jerald C. Sadoff3 and Marcus A. Horwitz4

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A New Recombinant Bacille Calmette-Guérin Vaccine Safely Induces Significantly Enhanced Tuberculosis-Specific Immunity in Human Volunteers

机译：一种新的重组BacilleCalmette-Guérin重组疫苗可安全地诱导人类志愿者显着增强的结核病特异性免疫力

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Background. One strategy for improving anti-tuberculosis (TB) vaccination involves the use of recombinant bacille Calmette-Guérin (rBCG) overexpressing protective TB antigens. rBCG30, which overexpresses the Mycobacterium tuberculosis secreted antigen Ag85b, was the first rBCG shown to induce significantly greater protection against TB in animals than parental BCG.

机译：背景。改善抗结核（TB）疫苗接种的一种策略涉及使用过度表达保护性TB抗原的重组杆菌Calmette-Guérin（rBCG）。过度表达结核分枝杆菌分泌的抗原Ag85b的rBCG30是第一个显示出比亲本BCG诱导明显增强的动物抗结核保护作用的rBCG。

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《Journal of Infectious Diseases》 |2008年第10期|p.1491-1501|共11页
作者
Daniel F. Hoft1 Azra Blazevic1 Getahun Abate1 Willem A. Hanekom5 Gilla Kaplan2 Jorge H. Soler2 Frank Weichold3 Larry Geiter3 Jerald C. Sadoff3 and Marcus A. Horwitz4;
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1Division of Immunobiology Departments of Internal Medicine and Molecular Biology, Saint Louis University Medical Center, and Center for Vaccine Development, Saint Louis, Missouri 2Laboratory of Mycobacterial Immunity and Pathogenesis, Public Health Research Institute, University of Medicine and Dentistry of New Jersey 3Aeras Global TB Vaccine Foundation, Rockville Pike, Maryland 4Departments of Internal Medicine and of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles 5South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa;

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1. A new recombinant bacille Calmette-Guerin vaccine safely induces significantly enhanced tuberculosis-specific immunity in human volunteers. [J] . Hoft DF, Blazevic A, Abate G, The Journal of Infectious Diseases . 2008,第10期

机译：一种新的重组杆菌Calmette-Guerin疫苗可在人类志愿者中安全诱导明显增强的结核特异性免疫。
2. Cell-Mediated Immunity Induced by Recombinant Mycobacterium bovis Bacille Calmette-Guérin Strains Against an Intracellular Bacterial Pathogen: Importance of Antigen Secretion or Membrane-Targeted Antigen Display as Lipoprotein for Vaccine Efficacy [J] . Leander Grode, Mischo Kursar, Joachim Fensterle, The journal of immunology . 2002,第4期

机译：重组牛分枝杆菌BacilleCalmette-Guérin菌株对细胞内细菌病原菌诱导的细胞介导的免疫：抗原分泌或膜靶向抗原展示作为脂蛋白的疫苗效力的重要性。
3. Efficiency of Recombinant Bacille Calmette-Guérin in Inducing Humoral and Cell Mediated Immunities against Human Immunodeficiency Virus Type 1 Third Variable Domain in Immunized Mice [J] . Kim Young Jae Yonsei Medical Journal . 2011,第1期

机译：重组芽孢杆菌Calmette-Guérin在免疫小鼠中诱导抗人免疫缺陷病毒1型第三可变域的体液和细胞介导的免疫的效率
4. Antitumor Immunity Induced by Recombinant Vaccine Alpha-Fetoprotein-Heat Shock Protein 70 Complex [C] . Xiaoping Wang, Lijie Zhang, Lijun Sun, Bioinformatics and Biomedical Engineering , 2009. ICBBE 2009 . 2009

机译：重组疫苗α-甲胎蛋白-热休克蛋白70复合物诱导的抗肿瘤免疫
5. Recombinant fowlpox-laryngotracheitis vaccine and recombinant herpes virus of turkey-laryngotracheitis vaccine induced immunity against infectious laryngotracheitis virus challenge. [D] . Luengo C., Amelia C. 1998

机译：重组鸡痘-喉气管炎疫苗和重组疱疹病毒-土耳其-喉气管炎疫苗可诱导抵抗传染性喉气管炎病毒攻击的免疫力。
6. Mycobacterial Codon Optimization Enhances Antigen Expression and Virus-Specific Immune Responses in Recombinant Mycobacterium bovis Bacille Calmette-Guérin Expressing Human Immunodeficiency Virus Type 1 Gag [O] . Masaru Kanekiyo, Kazuhiro Matsuo, Makiko Hamatake, 2005

机译：分枝杆菌密码子优化增强表达人免疫缺陷病毒1型gag的重组牛分枝杆菌BacilleCalmette-Guérin的抗原表达和病毒特异性免疫反应
7. Mycobacterial Codon Optimization Enhances Antigen Expression and Virus-Specific Immune Responses in Recombinant Mycobacterium bovis Bacille Calmette-Guérin Expressing Human Immunodeficiency Virus Type 1 Gag† [O] . Kanekiyo, Masaru, Matsuo, Kazuhiro, Hamatake, Makiko, 2005

机译：分枝杆菌密码子优化可增强表达人免疫缺陷病毒1型Gag†的重组牛分枝杆菌BacilleCalmette-Guérin的抗原表达和病毒特异性免疫反应。

A New Recombinant Bacille Calmette-Guérin Vaccine Safely Induces Significantly Enhanced Tuberculosis-Specific Immunity in Human Volunteers

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