Pathogenesis of H5N1 Influenza Virus Infections in Mice and Ferret Models Differs According to Respiratory Tract or Digestive System Exposure

摘要

BackgroundEpidemiologic, clinical, and laboratory data suggest that H5N1 influenza viruses are transmitted through and predominantly affect the respiratory system of mammals. Some data suggest digestive system involvement. However, direct evidence of alimentary transmission and infection in mammals is lacking