Sequencing and Analysis of JC Virus DNA From Natalizumab-Treated PML Patients

Carl E. Reid; Huo Li; Gargi Sur; Paul Carmillo; Steven Bushnell; Rich Tizard; Michele McAuliffe; Christopher Tonkin; Kenneth Simon; Susan Goelz; Paola Cinque; Leonid Gorelik

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Sequencing and Analysis of JC Virus DNA From Natalizumab-Treated PML Patients

机译：纳他珠单抗治疗的PML患者JC病毒DNA的测序和分析

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Background. Progressive multifocal leukoencephalopathy (PML) in natalizumab-treated MS patients is linked to JC virus (JCV) infection. JCV sequence variation and rearrangements influence viral pathogenicity and tropism. To better understand PML development, we analyzed viral DNA sequences in blood, CSF and/or urine of natalizumab-treated PML patients.

机译：背景。那他珠单抗治疗的MS患者中进行性多灶性白质脑病（PML）与JC病毒（JCV）感染有关。 JCV序列变异和重排影响病毒的致病性和嗜性。为了更好地了解PML的发展，我们分析了那他珠单抗治疗的PML患者血液，脑脊液和/或尿液中的病毒DNA序列。

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《Journal of Infectious Diseases》 |2011年第2期|p.237-244|共8页
作者
Carl E. Reid; Huo Li; Gargi Sur; Paul Carmillo; Steven Bushnell; Rich Tizard; Michele McAuliffe; Christopher Tonkin; Kenneth Simon; Susan Goelz; Paola Cinque; Leonid Gorelik;
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Biogen Idec Inc., Cambridge, Massachusetts;

Biogen Idec Inc., Cambridge, Massachusetts;

Biogen Idec Inc., Cambridge, Massachusetts;

Biogen Idec Inc., Cambridge, Massachusetts;

Biogen Idec Inc., Cambridge, Massachusetts;

Biogen Idec Inc., Cambridge, Massachusetts;

Biogen Idec Inc., Cambridge, Massachusetts;

Biogen Idec Inc., Cambridge, Massachusetts;

Biogen Idec Inc., Cambridge, Massachusetts;

Biogen Idec Inc., Cambridge, Massachusetts;

Department of Infectious Diseases, San Raffaele Scentific Institute, Milan, Italy;

Biogen Idec Inc., Cambridge, Massachusetts;

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1. Sequencing and analysis of JC virus DNA from natalizumab-treated PML patients. [J] . Reid CE, Li H, Sur G, The Journal of Infectious Diseases . 2011,第2期

机译：那他珠单抗治疗的PML患者的JC病毒DNA的测序和分析。
2. Natalizumab-treated patients at high risk for PML persistently excrete JC polyomavirus [J] . Werner Milton H., Huang DeRen Journal of neurovirology . 2016,第6期

机译：Natalizumab治疗的患者，PML的高风险持续缓解JC Polyomavirus
3. JC virus antibody index in natalizumab-treated patients: correlations with John Cunningham virus DNA and C-reactive protein level [J] . Roberta Lanzillo, Raffaele Liuzzi, Luca Vallefuoco, Therapeutics and Clinical Risk Management . 2014,第4期

机译：那他珠单抗治疗的患者的JC病毒抗体指数：与John Cunningham病毒DNA和C反应蛋白水平的相关性
4. Utility of ICE COLD-PCR Coupled to Sanger Sequencing or Next Generation Sequencing for Increased Mutation Detection Sensitivity During Patient Monitoring from Circulating Free DNA [C] . Katherine Richardson, Filip Janku, Ben Legendre, Molecular Medicine TRI-CON. . 2014

机译：冰冷PCR的效用偶联至Sanger测序或下一代测序，用于增加患者监测患者循环自由DNA期间的突变检测敏感性
5. Characterization of gamma herpesvirus viral DNA in peripheral blood of patients with virus-associated malignancies and analysis of CD8+ T cell responses to viral antigens in patients with Hodgkin's lymphoma. [D] . Lin, Lan. 2005

机译：霍乱金淋巴瘤患者病毒相关恶性肿瘤患者外周血中γ疱疹病毒DNA的表征以及CD8 + T细胞对病毒抗原的应答分析。
6. Sequencing and Analysis of JC Virus DNA From Natalizumab-Treated PML Patients [O] . Carl E. Reid, Huo Li, Gargi Sur, -1

机译：纳他珠单抗治疗的PML患者JC病毒DNA的测序和分析
7. Sequencing and Analysis of JC Virus DNA From Natalizumab-Treated PML Patients [O] . Reid, Carl E., Li, Huo, Sur, Gargi, 2011

机译：纳他珠单抗治疗的PML患者JC病毒DNA的测序和分析
8. Analysis of V3 Loop in Neutralization-Resistant Human Immunodeficiency Virus Type1 Variants by Direct Solid-Phase DNA Sequencing [R] . Wahlberg, J., Albert, J., Lundeberg, J., 1991

机译：直接固相DNa测序分析中和抗人免疫缺陷病毒1型变异体中的V3环

Sequencing and Analysis of JC Virus DNA From Natalizumab-Treated PML Patients

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