GLA-SE, a Synthetic Toll-like Receptor 4 Agonist, Enhances T-Cell Responses to Influenza Vaccine in Older Adults

Hayedeh Behzad1 Anke L. W. Huckriede3 Laura Haynes4 Beth Gentleman1 Krysta Coyle1 Jan C. Wilschut3 Tobias R. Kollmann2 Steven G. Reed5 and Janet E. McElhaney1

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GLA-SE, a Synthetic Toll-like Receptor 4 Agonist, Enhances T-Cell Responses to Influenza Vaccine in Older Adults

机译：GLA-SE，一种合成的Toll样受体4激动剂，增强了成年人对流感疫苗的T细胞应答

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Background. The decline in influenza vaccine efficacy in older adults is associated with a limited ability of current split-virus vaccines (SVVs) to stimulate cytotoxic T lymphocyte (CTL) responses required for clinical protection against influenza.

机译：背景。老年人中流感疫苗功效的下降与目前的分裂病毒疫苗（SVV）刺激临床预防流感所需的细胞毒性T淋巴细胞（CTL）反应能力有限有关。

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《Journal of Infectious Diseases》 |2012年第3期|p.466-473|共8页
作者
Hayedeh Behzad1 Anke L. W. Huckriede3 Laura Haynes4 Beth Gentleman1 Krysta Coyle1 Jan C. Wilschut3 Tobias R. Kollmann2 Steven G. Reed5 and Janet E. McElhaney1;
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1Vancouver Coastal Health Research Institute 2Children and Families Research Institute, University of British Columbia, Vancouver, Canada 3University Medical Center, Groningen, the Netherlands 4Trudeau Institute, Saranac Lake, New York 5Immune Design, Seattle, Washington;

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1. GLA-SE, a synthetic toll-like receptor 4 agonist, enhances T-cell responses to influenza vaccine in older adults [J] . BehzadH., HuckriedeA.L.W., HaynesL., The Journal of Infectious Diseases . 2012,第3期

机译：合成的Toll样受体4激动剂GLA-SE可增强老年人对流感疫苗的T细胞反应
2. Toll-Like Receptor 7 Agonist Imiquimod in Combination with Influenza Vaccine Expedites and Augments Humoral Immune Responses against Influenza A(H1N1)pdm09 Virus Infection in BALB/c Mice [J] . Anna J. X. Zhang, Can Li, Kelvin K. W. To, Clinical and vaccine immunology: CVI . 2014,第4期

机译：Toll样受体7激动剂咪喹莫特与流感疫苗结合并增强了BALB / c小鼠对A（H1N1）pdm09流感病毒感染的体液免疫反应
3. Synthetic Toll-Like Receptor 4 Agonist Enhances Vaccine Efficacy in an Experimental Model of Toxic Shock Syndrome [J] . Garry L. Morefield, Lynn D. Hawkins, Sally T. Ishizaka, Clinical and vaccine immunology: CVI . 2007,第11期

机译：合成的Toll样受体4激动剂在毒性休克综合症实验模型中提高疫苗效力
4. Dendritic cell targeted nano-vaccine delivery system engineered from a plant polymer based Toll-Like Receptor-4 agonist Inulin Acetate [C] . Siddharth S. Kesharwani, Mrigendra K.S. Rajput, Sunny Kumar, Society for Biomaterials annual meeting and exposition . 2017

机译：树突状细胞靶向纳米疫苗递送系统，由基于植物聚合物的Toll-Like Receptor-4激动剂菊糖乙酸酯设计而成
5. Age Associated Alterations in Toll-like Receptor Function of Human Dendritic Cells and Correlation With Influenza Vaccine Response. [D] . Panda, Alexander. 2012

机译：年龄相关的人类树突状细胞Toll样受体功能的变化及其与流感疫苗反应的相关性。
6. GLA-SE a Synthetic Toll-like Receptor 4 Agonist Enhances T-Cell Responses to Influenza Vaccine in Older Adults [O] . Hayedeh Behzad, Anke L. W. Huckriede, Laura Haynes, -1

机译：GLA-SE一种合成的Toll样受体4激动剂增强了成年人对流感疫苗的T细胞应答
7. GLA-SE, a Synthetic Toll-like Receptor 4 Agonist, Enhances T-Cell Responses to Influenza Vaccine in Older Adults [O] . Hayedeh Behzad, Anke L. W. Huckriede, Laura Haynes, 2011

机译：GLA-SE，一种合成的Toll样受体4激动剂，可增强老年人对流感疫苗的T细胞反应

GLA-SE, a Synthetic Toll-like Receptor 4 Agonist, Enhances T-Cell Responses to Influenza Vaccine in Older Adults

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