This study evaluated the histological changes in muscle tissue after limb lengthening in skeletally mature and immature rabbits and assessed the most vulnerable level of striated muscle. Twenty-three male domestic white rabbits, divided into six groups, were operated on and different lengthening protocols were used in the mature and immature rabbits. The histopathological changes were analysed by a semi-quantitative method according to the scoring system of Lee et al. (Acta Orthop Scand 64(6):688–692, 1993). After the evaluation of the five main degenerative parameters (muscle atrophy, muscle nuclei internalisation, degeneration of the muscle fibre, perimysial and endomysial fibrosis, haematomas), it is evident that the adults lengthened at a rate of 1.6 mm/day showed more degenerative changes than those lengthened at 0.8 mm/day. The adult 1.6 mm/day lengthened group presented significantly higher damage in the muscle and lower regenerative signs compared with the young 1.6 mm/day lengthened group, according to the summarised degenerative scores.
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机译：这项研究评估了骨骼成熟和未成熟兔子肢体延长后肢体肌肉组织的组织学变化，并评估了横纹肌最脆弱的水平。分为六组的23只雄性家兔进行了手术，在成熟和不成熟的兔子中使用了不同的加长方案。根据Lee等的评分系统，通过半定量分析组织病理学变化。 （Acta Orthop Scand 64（6）：688–692，1993）。在评估了五个主要的退化参数（肌肉萎缩，肌肉核内在化，肌肉纤维的退化，肌周和肌内膜纤维化，血肿）之后，很明显，成年人以1.6毫米/天的速度增长显示出更多的退化性变化比那些每天增加0.8毫米的时间更长。根据总结的退化评分，成人1.6 mm /天加长组与年轻的1.6 mm /天加长组相比，对肌肉的损伤明显更高，并且再生迹象更低。
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