BIOMOLECULAR FIELD EFFECT SENSORS (BIOFETS): FROM QUALITATIVE SENSING TO MULTIPLEXING, CALIBRATION AND QUANTITATIVE DETECTION FROM WHOLE BLOOD

摘要

Nanoscale field effect based sensors have emerged as a potential label-free diagnostic tool capable ofndetecting extremely low levels of biomolecules with fast response times. To date, successfulndetection of various biomolecular species ranging from small molecules to antibodies have beenndemonstrated, however, the lack of quantitative methods, sensor calibration techniques and ability tondetect charges in strong ionic strength environments has hindered their commercial application. Innthis paper we discuss a recent progress in this field directed primarily towards overcoming thenaforementioned obstacles.