Antiemetic effects of granisetron and dexamethasone combination therapy during cisplatin-containing chemotherapy for head and neck cancer: dexamethasone dosage verification trial

Mamoru Tsukuda; Junichi Ishitoya; Yasukazu Mikami; Hideki Matsuda; Hideaki Katori; Choichi Horiuchi; Machiko Kimura; Takahide Taguchi; Takafumi Yoshida; Junichi Nagao; Yasunori Sakuma; Gabor Toth

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Antiemetic effects of granisetron and dexamethasone combination therapy during cisplatin-containing chemotherapy for head and neck cancer: dexamethasone dosage verification trial

机译：Granisetron与地塞米松联合疗法在含顺铂化疗中治疗头颈部癌的止吐作用：地塞米松剂量验证试验

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摘要

Chemotherapy-induced nausea and vomiting (CINV) remains a significant problem for patients and is associated with a substantial deterioration in quality of life; appropriate use of antiemetic drugs is crucial in maintaining the quality of life in patients undergoing chemotherapy.

机译：化疗引起的恶心和呕吐（CINV）仍然是患者的主要问题，并且与生活质量的严重下降有关。适当使用止吐药对于维持接受化疗的患者的生活质量至关重要。

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来源
《International Journal of Clinical Oncology》 |2009年第4期|337-343|共7页
作者
Mamoru Tsukuda; Junichi Ishitoya; Yasukazu Mikami; Hideki Matsuda; Hideaki Katori; Choichi Horiuchi; Machiko Kimura; Takahide Taguchi; Takafumi Yoshida; Junichi Nagao; Yasunori Sakuma; Gabor Toth;
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作者单位

Department of Otolaryngology and Head and Neck Surgery Yokohama City University School of Medicine 3-9 Fukuura Kanazawa-ku Yokohama 236-0004 Japan;

Department of Otolaryngology Yokohama Medical Center Yokohama City University Yokohama Japan;

Department of Otolaryngology and Head and Neck Surgery Yokohama City University School of Medicine 3-9 Fukuura Kanazawa-ku Yokohama 236-0004 Japan;

Department of Otolaryngology and Head and Neck Surgery Yokohama City University School of Medicine 3-9 Fukuura Kanazawa-ku Yokohama 236-0004 Japan;

Department of Otolaryngology Yokohama Medical Center Yokohama City University Yokohama Japan;

Department of Otolaryngology and Head and Neck Surgery Yokohama City University School of Medicine 3-9 Fukuura Kanazawa-ku Yokohama 236-0004 Japan;

Department of Otolaryngology Yokohama Medical Center Yokohama City University Yokohama Japan;

Department of Otolaryngology and Head and Neck Surgery Yokohama City University School of Medicine 3-9 Fukuura Kanazawa-ku Yokohama 236-0004 Japan;

Department of Otolaryngology and Head and Neck Surgery Yokohama City University School of Medicine 3-9 Fukuura Kanazawa-ku Yokohama 236-0004 Japan;

Department of Otolaryngology and Head and Neck Surgery Yokohama City University School of Medicine 3-9 Fukuura Kanazawa-ku Yokohama 236-0004 Japan;

Department of Otolaryngology Yokohama Medical Center Yokohama City University Yokohama Japan;

Department of Otolaryngology and Head and Neck Surgery Yokohama City University School of Medicine 3-9 Fukuura Kanazawa-ku Yokohama 236-0004 Japan;

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正文语种 eng
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关键词
Chemotherapy; Nausea; Vomiting; Granisetron; Dexamethasone;

机译：化学疗法;恶心;呕吐;格兰尼司琼;地塞米松;

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专利

1. Antiemetic effects of granisetron and dexamethasone combination therapy during cisplatin-containing chemotherapy for head and neck cancer: dexamethasone dosage verification trial. [J] . Tsukuda M, Ishitoya J, Mikami Y International journal of clinical oncology . 2009,第4期

机译：Granisetron和地塞米松联合疗法在含顺铂化疗中治疗头颈部癌的止吐作用：地塞米松剂量验证试验。
2. Clinical evaluation of two antiemetic combinations palonosetron dexamethasone versus ondansetron dexamethasone in chemotherapy of head and neck cancer [J] . Singapore medical journal . 2010,第11期

机译：帕洛诺司琼地塞米松与恩丹西酮地塞米松两种止吐药联合治疗头颈部癌的临床评价
3. Clinical evaluation of two antiemetic combinations palonosetron dexamethasone versus ondansetron dexamethasone in chemotherapy of head and neck cancer [J] . Singapore medical journal . 2010,第11期

机译：帕洛诺司琼地塞米松与恩丹西酮地塞米松两种止吐药联合治疗头颈部癌的临床评价
4. A SINGLE-CENTER EXPERIENCE USING CHEMOTHERAPY WITH MELPHALAN-DEXAMETHASONE (M-DEX) IN PATIENTS WITH AL AMYLOIDOSIS AND ADVANCED ORGAN INVOLVEMENT NOT ELIGIBLE FOR HIGH-DOSE MELPHALAN THERAPY (HDM) [C] . U. Hegenbart, T. Bochtler, J.B. Dengler, International Symposium on Amyloidosis . 2008

机译：使用化学疗法的单中心经验与Melphalan-Dexamethasone（M-DEX）的Al淀粉样蛋白病和先进器官参与没有资格获得高剂量Melphalan治疗（HDM）
5. Symptoms, symptom distress, depressive symptoms, and uncertainty in newly diagnosed head and neck cancer patients receiving definitive radiotherapy with or without chemotherapy [D] . Haisfield-Wolfe, Mary Ellen 2009

机译：新诊断头颈癌患者接受明确放疗并伴或不伴化疗的症状，症状困扰，抑郁症状和不确定性
6. The antiemetic efficacy of tropisetron plus dexamethasone as compared with conventional metoclopramide-dexamethasone combination in Orientals receiving cisplatin chemotherapy: a randomized crossover trial [O] . D. T. T. CHUA, J. S. T. SHAM, G. K. H. AU, 1996

机译：在接受顺铂化疗的Orientals中与传统的甲氧氯普胺-地塞米松联合使用托吡司琼加地塞米松的止吐效果比较：一项随机交叉试验
7. The antiemetic efficacy of tropisetron plus dexamethasone as compared with conventional metoclopramide-dexamethasone combination in Orientals receiving cisplatin chemotherapy: a randomized crossover trial [O] . CHUA, D. T. T., SHAM, J. S. T., AU, G. K. H., 1996

机译：在接受顺铂化疗的Orientals中，与传统的甲氧氯普胺-地塞米松联合使用，托吡司琼加地塞米松的止吐效果比较：一项随机交叉试验
8. Effects of Chemotherapy on Astrocyte Density in the Rat Spinal Cord Dorsal Funiculi after Stab-wound Lesion: I. 5-Fluorouracil. II. Alphamethyl-tyrosine. III. Dexamethasone. IV. Simultaneous dexamethasone and 5-Fluorouracil. [R] . Grim, J. N. 1976

机译：化疗对大鼠脊髓损伤后脊髓背侧星形胶质细胞密度的影响：I。5-氟尿嘧啶。 II。 α-甲基酪氨酸。 III。地塞米松。 IV。同时使用地塞米松和5-氟尿嘧啶。

Antiemetic effects of granisetron and dexamethasone combination therapy during cisplatin-containing chemotherapy for head and neck cancer: dexamethasone dosage verification trial

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