Moderate renal dysfunction may not require a cisplatin dose reduction: a retrospective study of cancer patients with renal impairment

Tomoko Ogawa; Seiji Niho; Shunji Nagai; Takashi Kojima; Yoshiko Nishimura; Yuichiro Ohe; Naoki Kondo; Takuhiro Yamaguchi; Kazushi Endo; Keishiro Izumi; Hironobu Minami

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Moderate renal dysfunction may not require a cisplatin dose reduction: a retrospective study of cancer patients with renal impairment

机译：中度肾功能不全可能不需要降低顺铂剂量：一项对患有肾功能不全的癌症患者的回顾性研究

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摘要

Objective The aim of this study was to assess the tolerability of cisplatin (CDDP) in patients with moderate renal dysfunction.

机译：目的本研究旨在评估中度肾功能不全患者的顺铂（CDDP）耐受性。

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来源
《International Journal of Clinical Oncology》 |2013年第6期|977-982|共6页
作者
Tomoko Ogawa; Seiji Niho; Shunji Nagai; Takashi Kojima; Yoshiko Nishimura; Yuichiro Ohe; Naoki Kondo; Takuhiro Yamaguchi; Kazushi Endo; Keishiro Izumi; Hironobu Minami;
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作者单位

Division of Pharmacy National Cancer Center Hospital East">(1);

Division of Thoracic Oncology National Cancer Center Hospital East">(2);

Division of Oncology/Hematology National Cancer Center Hospital East">(3);

Division of Gastrointestinal Oncology National Cancer Center Hospital East">(4);

Division of Pharmacy National Cancer Center Hospital East">(1);

Division of Thoracic Oncology National Cancer Center Hospital East">(2);

Division of Pharmacy National Hospital Organization Tokyo Medical Center">(5);

Division of Biostatistics Tohoku University Graduate School of Medicine">(6);

Division of Pharmacy National Cancer Center Hospital East">(1);

Department of Drug Safety Management Meiji Pharmaceutical University">(7);

Division of Pharmacy National Cancer Center Hospital East">(1);

Division of Medical Oncology/Hematology Department of Medicine Kobe University Hospital and Graduate School of Medicine">(8);

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正文语种 eng
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关键词
Cisplatin; Renal impairment; Serum creatinine;

机译：顺铂;肾功能不全;血清肌酐;

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1. Moderate renal dysfunction may not require a cisplatin dose reduction: A retrospective study of cancer patients with renal impairment [J] . OgawaT., NihoS., NagaiS., International journal of clinical oncology . 2013,第6期

机译：中度肾功能不全可能无需降低顺铂剂量：一项对患有肾功能不全的癌症患者的回顾性研究
2. Dose-escalating and pharmacological study of bortezomib in adult cancer patients with impaired renal function: a National Cancer Institute Organ Dysfunction Working Group Study. [J] . Leal TB, Remick SC, Takimoto CH, Cancer chemotherapy and pharmacology. . 2011,第6期

机译：硼替佐米在肾功能受损的成年癌症患者中的剂量递增和药理研究：美国国家癌症研究所器官功能障碍工作组研究。
3. Dose-escalating and pharmacological study of bortezomib in adult cancer patients with impaired renal function: a National Cancer Institute Organ Dysfunction Working Group Study [J] . Ticiana B. Leal, Scot C. Remick, Chris H. Takimoto, Cancer Chemotherapy and Pharmacology . 2011,第6期

机译：硼替佐米在肾功能受损的成年癌症患者中的剂量递增和药理研究：美国国家癌症研究所的器官功能障碍工作组研究
4. Effect of Endotoxin on Acute Renal Failure Induced by High-Dose Cisplatin in Rats [C] . Shu Xiaohong, Li Meijun, Li Molin, 5th International Conference on Bioinformatics and Biomedical Engineering . 2011

机译：内毒素对大剂量顺铂所致大鼠急性肾衰竭的影响
5. Retrospective review of allopurinol dose and renal function in gout patients with and without allopurinol reactions. [D] . Silverberg, Miriam Shayna. 2010

机译：痛风患者有和没有别嘌呤醇反应的别嘌醇剂量和肾功能的回顾性回顾。
6. Dose-Escalating and Pharmacological Study of Bortezomib in Adult Cancer Patients With Impaired Renal Function: A National Cancer Institute Organ Dysfunction Working Group Study [O] . Ticiana B. Leal, Scot C. Remick, Chris H. Takimoto, -1

机译：剂量递增和硼替佐米在成人癌症患者肾功能受损药理研究：美国国家癌症研究所器官功能障碍工作组研究
7. P235Relation between myocardial deformation by three-dimensional speckle tracking analysis , control of the hypertension and functional capacity in patients with systemic hypertensionP236Obstructive sleep apnoea is often under-recognised in patients with acute myocardial infarction, but commonly contributes to left ventricular diastolic dysfunctionP237Intrinsic left ventricular dysfunction in Behcet disease in comparison with systemic disease activity: insights from speckle tracking echocardiographyP238Echocardiography changes during singleton and twin pregnancyP239Proposal of two new echocardiographic parameters for the differentiation of pre-capillary from post-capillary pulmonary hypertensionP240The coincidence of implanted device and number of electrodes with the presence of residual fibrotic tissue after transvenous leads extraction assessed in echocardiographic examP241Hemoglobin is an independent predictor of left ventricular hypertrophy in postmenopausal women but not in premenopausal womenP242Left ventricular longitudinal deformation impairment in patients with psoriasis is linked with immunologic activationP243Impaired diastolic functions and left atrial mechanical functions in patients with vitamin-D deficiencyP244Modification of cardiac and vascular function secondary to insulin resistanceP245Impaired right ventricular function is not related to serum galectin-3 concentration in patients with repaired tetralogy of fallotP246Age-adjusted indices of right ventricular (RV) longitudinal function do not adequately reflect the global RV contraction in children with repaired congenital heart defects and RV volume overloadP247Relationship between fractional flow reserve and dobutamine stress echocardiography in coronary artery diseaseP248A retrospective observational comparative study on the negative predictive value of nuclear testing vs. stress echo in pre-operative assessment for patients undergoing solid organ transplantionP249The detection of viable myocardium by dobutamine stress speckle tracking echocardiography in patients with coronary artery diseaseP250VO2 flattening during exercise in heart failure: evidence for a combined low cardiac output and inefficient O2 extractionP251 The dynamic assessment of alveolar-capillary barrier during exercise-echocardiography in heart failure patients with reduced ejection fractionP252The effect of exercise training on cardiac function during exercise stress echo in patients with type 2 diabetes and diastolic dysfunctionP253Age-related maximal exercise O2 extraction differences in a population of apparently healthy subjects at cardiovascular riskP254Difference in the changes of functional mitral regurgitation between semisupine ergometer and handgrip exerciseP255Correlation of annulus size assessed by echo 2d, 3d and multidetector computed tomography in patients undergoing transcatheter aortic valve implantationP256Mitral annulus dynamics: from normal to extensive mixomatous disease-a three-dimensional transoesophageal studyP257Left atrial appendage closure: an echo point of view of 55 casesP258Effect of catheter-based renal denervation on left ventricular function, mass and (un)twist with two-dimensional speckle tracking echocardiographyP259Associations of microRNAs gene expression in peripheral blood mononuclear cells and left ventricular global longitudinal peak strain in patients with essential hypertension [O] . I. Craciunescu, N. Ngiam, BJ. Sun, 2016

机译：心肌变形之间P235Relation通过三维斑点追踪分析，在患者全身hypertensionP236Obstructive睡眠呼吸暂停的高血压和功能的能力控制是经常根据公认在急性心肌梗死，但通常有助于左室舒张dysfunctionP237Intrinsic左心室功能紊乱中白塞氏病与全身性疾病的活性的比较：用于预毛细管的从植入装置和电极数目的毛细血管后肺hypertensionP240The巧合的分化与存在的两个新的超声心动图参数单和双pregnancyP239Proposal期间从斑点追踪echocardiographyP238Echocardiography变化的见解静脉引线后残留的纤维组织提取评估了超声心动图examP241Hemoglobin是绝经后妇女的左心室肥厚的独立预测因素，但不是在premen opausal womenP242Left心室纵向变形损害牛皮癣患者与免疫联activationP243Impaired舒张功能和左心房机械功能患者的心脏和血管功能继发于胰岛素的维生素-d deficiencyP244Modification resistanceP245Impaired右心室功能是不相关的血清半乳凝素3浓度患者右心室（RV）的纵向功能fallotP246Age调整指标的修复四部曲没有充分反映在冠状动脉diseaseP248A追溯血流储备分数和多巴酚丁胺超声心动图之间修复先天性心脏缺陷和RV容积overloadP247Relationship全球儿童RV收缩在术前评估核试验对应力回声的阴性预测值进行可行myocard的实体器官transplantionP249The检测患者的观察对比研究鎓通过多巴酚丁胺斑点跟踪超声心动图在患者的心脏衰竭锻炼期间冠状动脉diseaseP250VO2压扁：证据为一个组合的低心输出量和低效率的O2 extractionP251在心脏衰竭患者运动超声心动图中肺泡 - 毛细血管屏障的动态评估具有降低的喷射对心脏功能的运动锻炼的运动负荷超声过程中患者fractionP252The影响2型糖尿病患者和表面健康受试者的群体在心血管riskP254Difference在功能性二尖瓣返流的semisupine测力计和手柄之间的变化舒张dysfunctionP253Age相关的最大运动O2提取差异环大小的exerciseP255Correlation由回波2D评估，3d和多排的患者正在接受经导管主动脉瓣implantationP256Mitral环动力学计算机断层：从正常到广泛mixomatous疾病三dimensi Onal地区食道studyP257Left心耳闭合：视在左心室功能，质量和（UN）捻基于导管的肾去神经支配的55 casesP258Effect的在外周血单核细胞和左侧的微小RNA基因表达的二维散斑跟踪echocardiographyP259Associations回波点心室全球纵向应变峰值在原发性高血压患者
8. Guidance for Industry. Pharmacokinetics in Patients with Impaired Renal Function211 Study Design, Data Analysis, and Impact on Dosing and Labeling [R] . 1998

机译：工业指南。肾功能受损患者的药代动力学211研究设计，数据分析以及对剂量和标记的影响

Moderate renal dysfunction may not require a cisplatin dose reduction: a retrospective study of cancer patients with renal impairment

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