Kontrastmittel-induzierte Nephropathie

摘要

The use of iodinated contrast media (CM) continues to be a common cause of hospital-acquired acute renal failure (ARF) and its development increases the in-hospital mortality significantly. Thus, considerable efforts have been made to develop techniques to prevent acute renal failure, or to facilitate its recovery. Various strategies for the prevention of contrast-induced nephropathy (CN) have been studied, with conflicting results. Most studies used hydration as a basic intervention maneuver. Pharmaceutical interventions included the use of antioxidants, adenosine antagonists, sodium bicarbonate, domapine, prostaglandins, etc. Trials with new radio contrast agents (i. e., iodixanol) or gadolinium-containing agents has been limited to a few patients. The results of these trials will be reviewed by this paper, as well as the use of dialysis in order to treat and prevent contrast damage to the kidney.