Sepsis And Systemic Inflammatory Response Syndrome: Novel Therapeutic Approaches

摘要

Septic shock is a very serious medical condition caused by decreased tissue perfusion and oxygen delivery as a result of infection and sepsis. It can cause multiple organ failure and death. Sepsis is defined as the presence of bacteria or their toxins in blood or tissue and the systemic response that follows. A systemic inflammatory response syndrome (SIRS) triggered by infection is known as sepsis. Sepsis leading to at least one organ failure characterizes severe sepsis and septic shock is defined by severe sepsis accompanied by hypotension unresponsive to fluid resuscitation. Severe sepsis and septic shock are one of the leading causes of mortality among intensive care unit and post-operational care patients. The incidence of sepsis in North America has been reported to be 3.0 per 1000 population, which transforms into an annual number of 750,000 cases with 210,000 of them being fatal, and a large socio-economic burden. The incidence of mortality due to sepsis is increasing. To date, there is no known cure for sepsis and septic shock and treatment is mostly supportive.