A 3-D Microdosimetric Study on Blood Cells: A Permittivity Model of Cell Membrane and Stochastic Electromagnetic Analysis

摘要

This paper describes a microdosimetric study on erythrocytes in two parts: an assessment of the membrane dielectric model from permittivity measurements of erythrocyte solutions and its uncertainty, and a quasi-static electromagnetic (EM) analysis solving the Laplace equation, both analytically and numerically. To evaluate the role of the estimated uncertainty, a stochastic EM solution has been conducted; our results highlight the fundamental role of the dielectric modeling on the reliability of electric field values in the cell membrane. Numerical data, from 3-D cell models, confirm the dependence of the electric field distribution on the extra-cellular field polarization.