Study of Individual Patterns of Blood Protein Control during Simulation of Microgravity Effects on Humans

摘要

Blood samples taken from test subjects in a 7-day immersion experiment were assayed for blood proteins belonging to α1- and α2-globulin electrophoretic fractions: α1-antitrypsin (α1-AT), α1 acidic gly-coprotein (α1-AGP), ceruloplasmin (Cer), haptoglobin (Hp), α2-macroglobulin (α2-M), and apolipopro-tein A (ApoA). Immersion was shown to change the concentrations of all proteins studied; in some cases, concentration changes were observed upon the return to the normal state. In general, the set of identified effects corresponded to the pattern characteristic of an acute-phase response. Temporal profiles of α1-AGP, Cer, α2-M, Hp, and ApoA in all subjects were of the same type. Differences were detected primarily in the rate and amplitude of the concentration shifts. However, changes in the α1-AT content during immersion varied in different subjects. Although the ApoA content decreased in all subjects of the study group, in three subjects it dropped below the bottom reference range. In two of them, the baseline ApoA concentrations were also significantly lower compared to the other subjects. The results of this study suggest that monitoring of blood al-AT and ApoA in the period of adaptation to altered environmental conditions may be informative for assessment of individual adaptability.