Analysis of Serum Insulin, Cortisol, and Glucose Levels in the Settlement Inhabitants of the Yamalo-Nenets Autonomous Okrug

摘要

AbstractWe studied the concentrations of insulin, cortisol and glucose in blood serum of two groups of inhabitants of the Yamalo-Nenets Autonomous okrug (YaNAO) settlements (indigenous population and those who arrived from Central Russia). The insulin level in all groups (in indigenous and non-native population, men and women) was above 9.0 μIU/mL. The insulin level in non-native women and men was higher than that in the indigenous people by 19% and 26%, respectively. The tendency of increasing insulin level with age was revealed in both the indigenous and non-native inhabitants. The highest level of insulin and glucose was observed in Samburg and Kharampur settlements; the lowest, in Gyda settlement. The cortisol level was higher in men than in women. The reduced cortisol/insulin index was observed in both groups of men. A most significant decrease in the cortisol/insulin index and an increase inHOMA–IRindex were observed in nonnative men and women as compared with indigenous population. These data confirm the likelihood of the metabolic syndrome and type 2 diabetes mellitus in the YaNAO population, especially among non-native inhabitants.