Radioprotective effects of miso(fermented soy bean paste) against radiation in B6C3F1 mice: increased small intestinal crypt survival, crypt lengths and prolongation of average time to death

摘要

The radioprotective effect of miso, a fermentaion product from soy bean, was investigated with reference to the survival time, crypt survival and jejunum crypt length in male B6C3F1 mice. Miso at three different fermentation stages(early-, medium- and long-term fermented miso)was mixd in MF diet into biscuits at 10/100 and was administered from 1 week before irra- diation. Animal survival in the long-term fermented miso group was significantly prolonged as compared with the short-term fermented miso and MF cases after 8 Gy of ~60Co-γ-ray irradiation at a dose rate of 2Gy min~-1.