SUBCHRONIC TOXIC EFFECTS OF CADMIUM IN A RAT MODEL

摘要

Cadmium, a highly toxic heavy metal, is distributed widely in the general environment. This metal accumulates mainly in the liver and kidney as these organs are involved in the detoxification of foreign material. Evidence suggests that sub-chronic toxicity of cadmium may have effects on biochemical properties. In the present study, the sub-chronic toxic effects of cadmium (3.05 mg CdCl_2/kg body weight) on biochemical parameters were studied with experimental animals (rats). Result revealed that Cd increased creatinine and urea levels in blood but decreased iron level. Increases in aspartate transaminase (AST), ala-nine transaminase (ALT), lactate dehydrogenase (LDH) and creatine phosphokinase (CPK) activities were significant with regard to control group. Bioaccumulation of Cd was higher in kidney, followed by liver.