Biological Evaluation of Styrene Oligomers for Endocrine-disrupting Effects (II)

摘要

Endocrine-disrupting effects of styrene dimers (SD: NSD-01, 08, 09) and styrene trimers (ST: NST-01, racemic mixture; NST-03, diastereomeric mixtures; NST-12, diastereomeric mixtures), which are styrene oligomers present in polystyrene cups of instant noodles, together with styrene monomer (SM), were investigated with both in vitro and in vivo assay systems. In estrogen, androgen and thyroid hormone receptor binding assays, SM, SD and ST showed no binding activity to rat receptors. In Hershberger assay, SM, SD and ST did not induce anti-androgenic alteration in seminal vesicle, ventral prostate and levator ani muscle + bulbocavernosus muscle of castrated immature male rats. Furthermore, SM, SD and ST did not affect the serum prolactin concentration in ovariectomized female rats. Thus, it appears that these SM, SD and ST have no endocrine-disrupting effects.