Assessment of biomarkers in early stages of colon cancer in female f344 rats

摘要

4-Hydroxynonenal-2'-deoxyguanosine (HNE-dGuo) propano adducts are promu-tagenic DNA lesions originating from free radically-induced lipid peroxidation of po-lyunsaturated fatty acids. These adducts are not repaired by base excision repair, only by nucleotide excision repair.rnWe have developed a 20 months animal testing to induce chronic colitis in female F344 rats by repeated application of sodi-um dextran sulphate (MW 36000-50000) (DSS) via drinking water. We are interes-ted in the effect of a vitamin E and seleni-um dencient diet on the early stages of the development of colon cancer.