Total folate in enriched cereal-grain products in the United States following fortification

摘要

The full compliance date for mandatory folic acid fortification of enriched cerea1-grain products in the United States was l January, l998. There is currently a great interest in determining the effectiveness of this measure, which was instituted to increase the folate intakes of women of child-bearing age to reduce their risk of having a pregnancy affected by a neural tube birth defect. We surveyed 83 enriched cereal-grain products that are required to be fortified with folic acid under the new regulations and an addi- tional 79 foods that contain enriched cereal-grain ingredients or that are currently fortified with folic acid. Products were collected and analyzed between February l998 and April l999. Total folate was determined by microbiological assay using a tri-enzyme digestion. We compared analyzed values for total folate with amounts required by Federal regulations and/or with label declarations of folate content. For many enriched cereal-grain products, there were significant differences between amounts of folate found on analysis and amounts required by Federal regulations. In part because of this, label declarations of folate content were also in error. The high values found in some enriched cereal-grain products may represent manufacturers averages as well as the presence of higher-than-expected levels of endogenous folates. These results indicate that reliable food composition databases cannot be developed without extensive new data on the actual concentrations of folate in recently fortified enriched cereal-grain products as well as in products containing enriched cereal-grain ingredients. Reliance on older data bases or on compositional information that has a weak analytical underpinning wil1 lead to unsound estimates of folate intake, and hence, of the potential impact of the new fortification program.