New coumarins and anti-inflammatory constituents from Zanthoxylum avicennae

摘要

Zanthoxylum avicennae is commercially used as healthcare products for the improvement of chronic hepatitis and rheumatism. Its fruit is also used as a spice. Five new coumarins, 5'-methoxyauraptene (1), 6,5'-dimethoxyauraptene (2), 5'-methoxycollinin (3), 7-((2'E,5'E)-7'-methoxy-3',7'-dimethylocta-2',5'-dienyloxy)coumarin (4), and 6-methoxy-7-((2'E,5'E)-7'-methoxy-3',7'-dimethylocta-2',5'-dienyl-oxyjcoumarin (5), have been isolated from the leaves of Z avicennae, together with 15 known compounds (6-20). The structures of these new compounds were determined through spectroscopic and MS analyses. Compounds 6, 9-15, and 18 exhibited inhibition (IC_(50) ≤ 8.29 μg/ml) of superoxide anion generation by human neutrophils in response to formyl-_L-methionyl-L-leucyl-_L-phenylalanine/cytochalasin B (fMLP/ CB). Compounds 6, 10, 12, 14, and 18 inhibited fMLP/CB-induced elastase release with IC_(50) values ≤6.30 μg/ml.