Susceptibility in utero and upon neonatal exposure

摘要

Important determinants or principles in developmental toxicology are(1)genotype; (2)developmental stage when an insult is hitting;(3)mechanisms of action;(4) pharmocokinetics of the drug in the mother, conceptus and the neonate;(5)the manifestations of embryo/ foeto-and neonatal toxicity such as death, malforma- tions, growth inhibition and functional disturbances; and (6)dose-effect and dose-response relationships. The present paper will give a broad review of some Important developmental events and sensitivity periods, Such as the preimplantation period, the period of gastrulation, organogenesis and placental formation, The foetal and neonatal period during which xenobiotics Can cause perturbation in the normal development.