Prostate carcinoma and radiation therapy: therapeutic treatment resistance and strategies for targeted therapeutic intervention

摘要

Adenocarcinoma of the prostate remains a significant public health problem and a prevalentncancer in men. Prostate-specific antigen used as a biomarker has established a clear migrationnof patients towards earlier-stage disease at presentation. However, in spite of processnimprovements in traditional therapies including surgery, radiation therapy, and hormonenmanagement, there remains a significant cohort of patients with intermediate- to high-risknfeatures for poor outcome in spite of optimal use of traditional management. This papernfocuses on future treatment strategies integrating new therapeutic options with traditionalnmanagement, specifically to pinpoint new radiation therapy strategies.