Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015)

摘要

Introduction: Obesity, diabetes, atherosclerosis, hypertension, dyslipidemia, and metabolic syndrome are synergistically operating diseases that endanger human health. Many studies provide evidence for excessive free fatty acid (FFA) as the pathogenic factor of these diseases. Fatty acid binding proteins (FABPs), which are responsible for the transfer of FFA to different cell compartments, play a key role in cellular functions. Therefore, the discovery and application of FABP inhibitors may be a potential strategy to control obesity, atherosclerosis, diabetes, and metabolic syndrome diseases in humans.