Spontaneous Neoplastic Lesions in Aged Sprague-Dawley Rats

摘要

Noplastic lesions were observed in untreated aged Sprague Dawley(SD)rats throughout their lifespan starting at 5 weeks. Their mean survial times were 89 to 105 weeks of age. The total tumor incidences were 70 to 76.7/100 and 87 to 95.8/100 in males and females, respectively. The common neoplasmas were pituitary adenoma and adrenal pheochromocytoma in both sexes, testicular Leydig cell tumor in males and mammary gland tumors, thyroidal C-cell adenoma and uterine stromal polyp in females.