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首页> 外文期刊>Environmental Toxicology and Chemistry >Effects of acute 2, 3, 7, 8-terachlorodibenzo-p-dioxin exposure on plasma thyroid and sex steroid hormone concentrations and estrogen receptor levels in adult great blue herons
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Effects of acute 2, 3, 7, 8-terachlorodibenzo-p-dioxin exposure on plasma thyroid and sex steroid hormone concentrations and estrogen receptor levels in adult great blue herons

机译:急性2、3、7、8-四氯二苯并-对-二恶英暴露对成年大蓝鹭血浆甲状腺和性类固醇激素浓度以及雌激素受体水平的影响

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摘要

Adult great blue herons (Ardea herodias) were exposed intraperitoneally to a single dose of 20 μg/kg body weight of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) and sacrificed after 14 d. Approximately 1.9/100 of the total TCDD dose was measured in the liver. No difference were found in liver weight or liver to body weight ratio between control and TCDD-treated birds. Hepatic microsomal ethoxyresorufin O-deethylase (EROS) activity was induced sixfold above control activities in TCDD-exposed Herons (p<0.001).
机译:成年大蓝鹭(Ardea herodias)腹膜内暴露于20μg/ kg体重的2、3、7、8-四氯二苯并对二恶英(TCDD)单剂量,并在14 d后处死。在肝脏中测得的总TCDD剂量约为1.9 / 100。在对照组和经TCDD处理的禽类之间,肝脏重量或肝脏与体重之比没有差异。暴露于TCDD的苍鹭的肝微粒体乙氧基间苯二酚O-脱乙基酶(EROS)活性是对照活性的六倍(p <0.001)。

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