FIXED-EFFECT-LEVEL TOXICITY EQUIVALENTS-A SUITABLE PARAMETER FOR ASSESSING ETHOXYRESORUFIN-O-DEETHYLASE INDUCTION POTENCY IN COMPLEX ENVIRONMENTAL SAMPLES

摘要

Within the scope of bioassay-directed identification of dioxin-like toxicants in complex environmental samples, CE50- based and fixed-effect-level-based 2,3,7,,8-tetrachlorodibenzo-p-dioxin(TCDD)toxicity equivalents(TEQs)were compared to assess 7-ethoxyresorufin-O-deethylase(EROD)inducing potency of sediment fractions using the rainbow trout liver cell line RTL-W1 as bioassay system. Toxicity equivalents on the basis of fixed effect levels are suggested in order to minimize interpretation problems due to the superposition of enzyme-inducing and enzyme-inhibiting effects.