Chemical toxicity indicators for human health: Case study for classification of chronic noncancer chemical hazards in Life-cycle assessment

摘要

The classification scheme for human health indicators in life-cycle assessment(LCA) and other toxicity scores is proposed based on identifiable target organ or system toxicity. This scheme represents a compromise between a subjective single overall score and highly detailed toxic mechanisms of action. A case study was used to evaluate the proposed classification scheme. The data on 117 high production volume organic chemicals were extracted from the U.S. Environmental Protection Agency(U.S. EPA) integrated risk information system(IRIS) database. Based on the critical effect listed in the database, almost all chemicals were easily and clearly classified into the proposed categories.