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首页> 外文期刊>Environmental toxicology and pharmacology >Genetic polymorphisms study of pharmacogenomic VIP variants in Han ethnic of China's Shaanxi province
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Genetic polymorphisms study of pharmacogenomic VIP variants in Han ethnic of China's Shaanxi province

机译：陕西汉族人群药物基因组VIP变异的遗传多态性研究

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摘要

Background: Multiple factors include genetic and non-genetic interactions induce to different drug response among different individuals. Lots of researches proved that different frequencies of genetic variants exists different ethnic groups. The aim of this study was to screen Han volunteers in Shaanxi for VIP gene polymorphisms. Materials and methods: We genotyped 80 Very Important Pharmacogenes (VIP) (selected from the Phar-mGKB database) in 192 unrelated, healthy Han ethnic adults from Shaanxi, the northwest of China, and then analyzed genotyping data wtih Structure and F-statistics (Fst) analysis. Results: We compared our data with 15 other populations (Deng, Kyrgyz, Tajik, Uygur and 11 HapMap populations), and found the frequency distribution of Han population in Shaanxi is most similar with CHB. Also, Structure and Fst showed that Shaanxi Han has a closest genetic background with CHB. Conclusions: Our study have supplemented the Han Chinese data related to pharmacogenomics and illustrated differences in genotypic frequencies of selected VIP variants' among the Han population and 15 other populations.
机译：背景：多种因素包括导致不同个体之间不同药物反应的遗传和非遗传相互作用。许多研究证明不同频率的遗传变异存在不同的种族群体。这项研究的目的是筛选陕西汉族志愿者的VIP基因多态性。材料和方法：我们对来自中国陕西省西北部的192名健康的汉族成年人中80个非常重要的药物原（VIP）（从Phar-mGKB数据库中选择）进行了基因分型，然后通过结构和F统计分析了基因分型数据（ Fst）分析。结果：我们将我们的数据与其他15个人口（邓，吉尔吉斯，塔吉克，维吾尔族和11个HapMap人口）进行了比较，发现陕西汉族人口的频率分布与CHB最相似。另外，结构和Fst表明陕西汉族人与CHB的遗传背景最接近。结论：我们的研究补充了与药物基因组学相关的汉族数据，并说明了汉族人群和其他15个人群在选定VIP变体的基因型频率上的差异。

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  • 来源
    《Environmental toxicology and pharmacology》 |2016年第9期|27-35|共9页
  • 作者

    Tianbo Jin; Ruimin Zhao; Xugang Shi; Na He; Xue He; Yongri Ouyang; Hong Wang; Bo Wang; Longli Kang; Dongya Yuan;

  • 作者单位

    Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi 712082, China,Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang 712082, China,Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi 712082, China,National Engineering Research Center for Miniaturized Detection Systems, School of Life Sciences, Northwest University, Xi'an, Shaanxi 710069, China;

    Otorhinolaryngological, Neck Surgery Department, School of Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China;

    Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi 712082, China,Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang 712082, China,Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi 712082, China,National Engineering Research Center for Miniaturized Detection Systems, School of Life Sciences, Northwest University, Xi'an, Shaanxi 710069, China;

    Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi 712082, China,Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang 712082, China,Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi 712082, China;

    Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi 712082, China,Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang 712082, China,Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi 712082, China;

    National Engineering Research Center for Miniaturized Detection Systems, School of Life Sciences, Northwest University, Xi'an, Shaanxi 710069, China;

    National Engineering Research Center for Miniaturized Detection Systems, School of Life Sciences, Northwest University, Xi'an, Shaanxi 710069, China;

    National Engineering Research Center for Miniaturized Detection Systems, School of Life Sciences, Northwest University, Xi'an, Shaanxi 710069, China;

    Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi 712082, China,Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang 712082, China,Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi 712082, China;

    Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi 712082, China,Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang 712082, China,Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi 712082, China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Pharmacogenomics; Genetic polymorphisms; Han ethnic; VIP; Variant;

    机译：药物基因组学遗传多态性;汉族;VIP;变体;

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