Screening Assay for Dioxin-like Compounds Based on Competitive Binding to the Murine Hepatic Ah Receptor. 2. Application to Environmental Samples

摘要

A series of environmental samples, comprising fly ash, caustic wash water from regeneration of a petrochemical reforming catalyst, fish homogenates, soil, and pulp mill sludge, were analyzed for dioxin-like compounds by an assay involving competitive binding of a reference radioligand and an extract from the sample to mouse hepatic Ah receptor; the results were compared with GC/MS. The bioassay generally gave higher TEQ values than GC/MS. Further analysis by GC/MS in most cases identified much of the additional Ah receptor-active material as coplanar PCBs and PAHs.