Comparison of Two Cell-Based Assays for Screening Dioxin and Dioxin-Like Compounds in Sediments

摘要

The purpose of this technical note is to report the results of studies comparing two cell-based assays as screening tools for dioxins and related compounds in sediments. The Reuber H4IIE rat hepatoma cell line and the recombinant 101L human hepatoma cell line were used to assay 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) toxic equivalents (TEQs) in split samples of the same sediment extracts. The two methods were compared for sensitivity and correlation with analytical chemistry results. An interlaboratory comparison of results obtained with the 101L cells was performed.