Air pollution and hospitalization for epilepsy in Chile

摘要

Objective: To determine the association between gaseous and fine particulate air pollution (PM_(2.5)) andrnepilepsy in a general population sample.rnMethod: A daily time-series analyses tested the association between daily hospitalization for epilepsy inrnseven Chilean urban centers during the period 2001 and 2005. Results were adjusted for long term trends,rnday-of-the-week, and average humidex on the day of hospitalization and the day before.rnResults: Pooled city estimates of relative risk (95% CI) of hospitalization for epilepsy associated with changesrnin pollutant concentrations equivalent to their interquartile range were: 1.098(1.045, 1.155) for carbonrnmonoxide (CO); 1.100 (1.025,1.181) for ozone O_3; 1.085 (1.03,1.144) for sulfur dioxide (SO_2); 1.108 (1.021,rn1.204) for nitrogen dioxide (NO_2); 1.083(1.038, 1.13) for particulate matter≤10μm diameter (PM_(10); andrn1.065(1.002, 1.132) for fine particulate matter<2.5μm diameter (PM_(2.5). These results were notrnsignificantly influenced by age, sex, or season.rnInterpretation: Air pollution may be a risk factor for hospitalization for epilepsy.