Expression of Prostaglandin E Receptor EP_4 Subtype in Rat Adrenal Zona Glomerulosa: Involvement in Aldosterone Release

摘要

We examined the role of prostaglandin (PG) E receptors in the secretion of aldosterone. PGE_2 is known to exert its various biological functions by binding to PGE receptors. There are four subtypes of PGE receptors, EP_1, EP_2, and EP_4. Among the PGE receptors EP_2 and EP_4 subtypes are coupled to Gs protein and stimulate Adenylyl cyclase. In this study, PGE_2 caused a dose-dependent increase in aldosterone production from the rat Adrenal zona glomerulosa cells in vitro accompanied with an increase in intracellular cAMP concentration.