Increased ACTH Levels Do not Alter Renal 11β-Hydroxysteroid Dehydrogenase Type 2 Gene Expression in the Sheep

摘要

The regulation of renal 11β-hydroxysteroid dehydrogenase type 2 (11βHSD2) gene expression is poorly understood. Inhibition of expression can result in hypertension. An example of this is in ectopic adrenocor- ticotropin (ACTH) syndrome (EAS). Inhibition of 11βHSD2 activity is suggested by the observed increased ratio of cortisol to cortisone in both plasma and urine. To investigate whether ACTH or ACTH-dependent steroids can modulate renal 11βHSD2 gene expression we analysed renal 11βHSD2 mRNA levels after treatment with ACTH of 1 H and 24 H and demonstrated no change in the levels of gene expression.