Effect of 2-Oxa-1, 25-Dihydroxyvitamin D_3 on Human Thyroid Cancer Cell Growth

摘要

To examine whether synthetic vitamin D_3 analog, 22-oxa-1, 25 (OH)_2D_3 (oct) has an inhibitory effect on the growth of thyroild carcinoma, we tested the in vitro and in vivo effects of OCT on the growth of a well- differentiated thyroid cancer cell line, NPA. OCT bound to its receptor at the same rate as 1,25 (OH)_2D_3, and in- hibited the proliferation of NPA cells in vitro in a dose-dependent manner, similar to that observed with 1.25 (OH)_2D_3.