Antiviral and Cytotoxic Activity of Netropsin Derivatives in Vero Cells Infected with Vaccinia Virus and Herpes Simplex Virus Type I

摘要

Currently, the population has not been vaccinated against variola virus; as a result, children and the majority of adult population younger than 27-30 years old are not immune to smallpox. In view of this, designing and synthesis of new compound that can effectively inhibit reproduction of orthopox viruses is a relevant problem of both theoretical and practical significance. The relevance of these studies increases with regard for the fact that variola virus may be used as a biological terrorism agent. A possible approach to curing infections caused by orthopox viruses is to use compounds that selectively bind to viral DNA and inhibit the activity of the key viral DNA-binding proteins. Earlier, we discovered that dimeric netropsin derivatives effectively suppressed reproduction of herpes simplex virus type I in experiments performed in Vero cells and in laboratory animals [1, 2].