2-AMINO-5,6-DIFLUOR-1-(BETA-D-RIBOFURANOSYL)-BENZIMIDAZOLE, METHOD FOR PRODUCTION AND ANTIVIRAL ACTIVITY IN TERMS OF HERPES SIMPLEX VIRUS TYPE I

摘要

FIELD: pharmacology.;SUBSTANCE: invention relates to a 2-amino-5,6-difluoro-1-(beta-D-ribofuranosyl)-benzimidazole of formula (I) suitable for treatment of herpes, and a method for its preparation that can be used in the pharmaceutical industry: ; (I). ;The proposed method involves ortho-phenylenediamine condensing with bromocyanide, followed by bromohydrate removal with sodium carbonate and a reaction of obtained base transribosylation with uridine in the presence of catalytic amounts of uridine phosphorylase and purine nucleoside phosphorylase.;EFFECT: new effective anti-herpes virus compound is proposed, including that against variants of the virus resistant to the action of basic antiherpetic drugs, as well as a new effective method for obtaining.;3 cl, 3 ex, 4 dwg