Pattern of Proteasome Expression in WALKER 256 Tumor Cells after Their Transplantation into the Brattleboro Rats with Genetic Defect of Vasopressin Synthesis

摘要

We have shown previously that tumor cell growth depends of the ratio of different proteasome forms [1]. In the growing cells of mouse ascite carcinoma Krebs-II, the expression of the constitutive 26S protea-somes is significantly higher than in cells of healthy organs, whereas the expression of immune 26S protea-somes is decreased by an order of magnitude. A large pool of the constitutive 26S proteasomes is required for regulating the cell cycle of intensely proliferating malignant cells; at the same time, a drop in the content of immune proteasomes seems to enable tumor cells to escape immune control. Nevertheless, it remains unclear to what extent malignant tumor regression depends on the proteasome pool.